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The PathnSitu team consists of world class scientific advisors and hands-on technical advisors that bring over two decades of global tissue diagnostics experience directly to the customer. The company is founded upon a fresh, dynamic perspective that brings energy and motivation to develop quality products for better patient care. Our dedication to your lab will streamline your staining process and reduce the turnaround time, all at affordable pricing. Our company motto is to make cancer diagnosis effective and affordable.
Essential reagents and accessories ensuring smooth laboratory workflows.
Advanced detection kits designed for clarity and enhanced sensitivity in assays.
Precision-engineered instruments built for accuracy and efficiency in research.
Reliable staining solutions that enhance visualization and tissue differentiation.
Value, innovation and friendliness. Those are the key traits Motic has tirelessly worked to embody since it was founded in 1988. It is through our passion for providing value, our boundless creativity, and our unwavering dedication to the customer, that Motic has spent the last 30+ years becoming a leading manufacturer of microscopy tools with over 2000 employees and offices all over the world.We are delighted to announce partnership of PathnSitu with MOTIC for its synergy of wide range of microscopes for advanced schools, university usage, clinical setups, Pharma industries, Pathology labs, Medical Colleges, Veterinary Colleges providing a one stop solution to our customers.
Tissue microarrays are paraffin blocks produced by extracting cylindrical tissue cores from different paraffin donor blocks and re-embedding these into a single recipient (microarray) block at defined array coordinates. Using this technique, multiple tissue samples can be arrayed into a single paraffin block. The use of tissue microarrays in combination with special applications like immunohistochemistry, immunofluorescence and fluorescent in-situ hybridization etc.. has been a preferred method to study and validate cancer biomarkers, drug discovery, product quality control in various diseased patient cohorts. We offer a wide range of tissue microarray molds and needles/punches.
Brilliant fluorescent staining systems for advanced visualization and research clarity.
High-specificity antibodies crafted for precise immunohistochemistry and diagnostics.
Advanced detection kits designed for clarity and enhanced sensitivity in assays.
Explore our latest scientific and laboratory kits designed for precision, performance, and reliability.
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View DetailsReverse transcription is the process of synthesis of DNA from RNA template. This process is driven by RNA-dependent DNA polymerases, also known as reverse transcriptases. A reverse transcriptase synthesizes a complementary DNA (cDNA) strand from the given RNA template strand aiding to produce cDNA libraries. cDNA libraries contain DNA copies of mRNA from cells and tissues and are used to understand actively expressed genes and their functions at a specific point of time.
View DetailsOne step RT-PCR combines the processes of cDNA synthesis and subsequent amplification of the cDNA to billions of copies. It occurs in a single tube and in a single step from RNA to ds DNA. This reaction set-up can help simplify the work-flow, reduces variation and minimizes possible contamination due to frequent sample handling. It is a time-saving process and eliminates the steps of pipetting of cDNA product.
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Polymerase Chain Reaction, most commonly known as PCR, is a technique based on the ability of DNA polymerase to synthesize complementary DNA strand to the given template strand. It allows amplification of very small sample or a short segment of DNA into millions and billions of copies rapidly. It is the most common and indispensable technique in a research and diagnostic laboratory.
View DetailsPMS2, a mismatch repair endonuclease, is a member of a family of genes involved in DNA mismatch repair. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. Along with MLH1, MSH2 and MSH6, PMS2 antibody is helpful in diagnosis of MSI. An IHC study conducted by Mayo clinic on 535 cases with MSI-high, 90% of the tumors showed loss of MLH1, MSH2 and/or MSH6 expression, while 70% of the remaining cases showed isolated loss of PMS2 expression. The loss of PMS2 was associated with young age of diagnosis and right-sided location but not with a striking family history of cancer. Endometrial carcinomas are the most common non-colorectal cancers occur in HNPCC. The most common IHC abnormality in endometrial carcinomas with MSI was concurrent loss of MLH1/PMS2. Adding of PMS2 and MSH6 to MLH1 and MSH2 antibodies increased sensitivity for diagnosis of MSI. Tumors with low-level MSI show unfavorable pathological characteristics compared to tumors with no and tumors with high-level MSI.
View DetailsMLH1 is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been shown that immunohistochemical analysis of MLH1 expression is a practical and reliable method for the routine detection of the vast majority of colorectal carcinomas with high-frequency MSI, which are frequently identified in hereditary nonpolyposis cancer (HNPCC) and are account for 15% of sporadic colorectal cancer. MLH1 negative tumors maybe associated with a longer disease-free survival.
View DetailsRecognizes a protein of 31kDa, which is identified as MTAP (5\'-deoxy-5\'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
View DetailsWe specialize in creating advanced scientific instruments tailored to modern research and industrial needs. From concept to prototype and final deployment, our team blends innovation, precision engineering, and user-centric design to deliver reliable and high-performance solutions.
Our contract manufacturing services provide end-to-end support for producing high-quality scientific and laboratory equipment. With strict quality control, scalable production, and expertise across multiple technologies, we ensure timely delivery and flawless execution for all manufacturing requirements.
We offer comprehensive analytical services designed to meet the rigorous standards of research, biotechnology, pharmaceuticals, and diagnostics. Our state-of-the-art facilities and experienced scientists deliver accurate, reproducible, and fast results for a wide range of analytical needs.
Partner with us for OEM solutions that combine your vision with our technical excellence. We support brands by developing customized instruments, components, and technologies that seamlessly integrate into your product line with superior performance and reliability.
Our custom antibody production service provides highly specific and sensitive antibodies tailored to your research or diagnostic application. We deliver monoclonal and polyclonal antibodies with strict quality standards, optimized protocols, and expert project support at every stage.
We provide end-to-end molecular biology services, including gene cloning, expression optimization, and high-purity protein isolation. Our streamlined workflows and advanced technologies ensure efficient turnaround, high yields, and consistent quality for all protein-related projects.